Ionically Cross-linked Pectin-alginate Hydrogel Beads for Prolonged Release of Glibenclamide

Background: Glibenclamide is a second-generation sulfonylurea extensively associated with the therapy of diabetes mellitus. A sustained release drug in gastrointestinal tract may aid maintaining therapeutic range for an extended period time. Alginate and pectin are two commonly used biopolymers field delivery favourable biodegradation biocompatibility. Materials Methods: In present study, pectin-alginate hydrogel beads were developed intestinal glibenclamide. barium ion (Ba+2) induced ionic gelation technique was employed synthesising pH sensitive by varying ratio sodium alginate pectin. The FTIR study confirmed compatibility between drugs polymers. evaluated scanning electron microscopic entrapment efficiency (DEE), bead size, swelling ratio, in-vitro dissolution study. Results: images exhibited hemispherical shaped cracked rough surfaces. DEE reported to vary 78.38 ± 1.17 % 92.08 0.64 %. mean size found be 668.81 2.10 μm 984.62 2.84 μm. dependent observed, which indicated restricted water uptake acidic medium increased alkaline pH. demonstrated increasing concentration up 12 h. Conclusion: findings successful development Ba+2 ions cross-linked